Immunosuppression by viral N proteins

Immunosuppression by viral N proteins

Arenaviruses and Coronaviruses (CoV) are enveloped RNA viruses. The nucleoproteins (N) of these viruses (termed nucleocapsid in CoV) play a key role in the formation of the viral ribonucleoprotein (RNP) complexes and in causing type I interferon (IFN) suppression. The primary function of the N proteins of CoV, such as the severe acute respiratory syndrome coronavirus (SARS-CoV), and of arenavir...

Potentiation of viral carcinogenesis by immunosuppression.

Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells

Among cells of the immune system, CD11c(+) and DEC-205(+) splenic dendritic cells primarily express the cellular receptor (alpha-dystroglycan [alpha-DG]) for lymphocytic choriomeningitis virus (LCMV). By selection, strains and variants of LCMV that bind alpha-DG with high affinity are associated with virus replication in the white pulp, show preferential replication in a majority of CD11c(+) an...

Interaction of viral oncogenic proteins with the Wnt signaling pathway

It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses, plays an important role in viral carcinogenes...

The N-Terminal of Aquareovirus NS80 Is Required for Interacting with Viral Proteins and Viral Replication

Reovirus replication and assembly occurs within viral inclusion bodies that formed in specific intracellular compartments of cytoplasm in infected cells. Previous study indicated that aquareovirus NS80 is able to form inclusion bodies, and also can retain viral proteins within its inclusions. To better understand how NS80 performed in viral replication and assembly, the functional regions of NS...